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KMID : 0363620090300060044
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 6 p.44 ~ p.52
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Comparative Study of Extraction Solvents on the Anti-inflammatory Effects of Scutellaria baicalensis
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Yoon Tae-Sook
Cheon Myeong-Sook
Kim Seung-Ju
Lee A-Young
Moon Byeong-Cheol
Chun Jin-Mi
Choo Byung-Kil
Kim Ho-Kyoung
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Abstract
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Objectives: This study was performed to evaluate the influence of different extracting solvents (water, methanol,
ethanol, or n-hexane) on the anti-inflammatory efficacy of Scutellaria baicalensis (Lamiaceae), which has been used widely as a traditional herbal medicine for its anti-inflammatory properties.
Methods: The ability of each extract to inhibit the production of pro-inflammatory mediators such as NO, TNF-α,
and PGE2 by lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells was measured.
Results: The results showed that extraction solvents (except n-hexane) for S. baicalensis showed significant inhibitory effects on NO, TNF-α and PGE2 production. Especially, methanol was the solvent with the greatest activity against NO and PGE2 production. However, there was no difference between the extracts for inhibitory activity of TNF-α.
Conclusion: The present study suggests that methanol is a superior extraction solvent than water, ethanol, or n-hexane for maintaining the anti-inflammatory effects of S. baicalensis.
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KEYWORD
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Scutellaria baicalensis, anti-inflammatory, extracting solvent, NO, TNF-α, PGE2
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